Interplay of Placental DNA Methylation and Maternal Insulin Sensitivity in Pregnancy
نویسندگان
چکیده
منابع مشابه
Maternal Glucose Tolerance in Pregnancy Affects Fetal Insulin Sensitivity
OBJECTIVE Offspring of mothers with impaired glucose tolerance are far more likely to develop type 2 diabetes. We tested the hypothesis that maternal glucose tolerance in pregnancy affects fetal insulin sensitivity or beta-cell function. RESEARCH DESIGN AND METHODS In a prospective singleton pregnancy cohort study, we analyzed glucose, insulin, and proinsulin concentrations in maternal blood ...
متن کاملMaternal smoking during pregnancy is associated with mitochondrial DNA methylation
Maternal smoking during pregnancy (MSDP) has detrimental effects on fetal development and on the health of the offspring into adulthood. Energy homeostasis through ATP production via the mitochondria (mt) plays a key role during pregnancy. This study aimed to determine if MSDP resulted in differences in DNA methylation to the placental mitochondrial chromosome at the transcription and replicati...
متن کاملSelf-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study
Human placenta is a fetal-derived tissue that offers a unique sample of epigenetic and environmental exposures present in utero. In the MARBLES prospective pregnancy study of high-risk younger siblings of children with autism spectrum disorder (ASD), pregnancy and environmental factors collected by maternal interviews were examined as predictors of placental DNA methylation, including partially...
متن کاملDNA Methylation and Its Role in the Development of Leukemia
Epigenetic changes play an essential role in cancer pathogenesis. It has been established by next-generation sequencing that more than 50% of the human cancers carry mutations in mechanisms involved in the organization of the chromatin and epigenetic regulations. DNA methylation is among the most common epigenetic changes in leukemia. In contrast to DNA mutations which are passively inherited f...
متن کاملThe role and importance of DNA methylation in spermatogenesis process
Background: DNA methylation is one of the epigenetic marks that are created by de novo DNA methylation and be maintained through cell division. This process is catalyzed by DNA methyltransferases. DNA methylation establishment in germ line is important, since they have the potential to regulate gene expression in offspring and improper DNA methylation patterns in germ lines has serious conseque...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes
سال: 2019
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db19-0798